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Oral antibiotic therapy is non-inferior to intravenous antibiotic therapy when used during the first 6 weeks in management of bone and joint infection, and saves around £2740 per patient.

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Matthew Scarborough 1,*, Ho Kwong Li 1,2, Ines Rombach 3, Rhea Zambellas 3, A Sarah Walker 4,5, Martin McNally 1, Bridget Atkins 1, Michelle Kümin 5, Benjamin A Lipsky 6, Harriet Hughes 7, Deepa Bose 8, Simon Warren 9,10, Damien Mack 9,10, Jonathan Folb 11, Elinor Moore 12, Neil Jenkins 13, Susan Hopkins 10, R Andrew Seaton 14, Carolyn Hemsley 15, Jonathan Sandoe 16, Ila Aggarwal 17, Simon Ellis 18, Rebecca Sutherland 19, Claudia Geue 20, Nicola McMeekin 20, Claire Scarborough 5, John Paul 21, Graham Cooke 2, Jennifer Bostock 22, Elham Khatamzas 1, Nick Wong 1, Andrew Brent 1, Jose Lomas 1, Philippa Matthews 1,5, Tri Wangrangsimakul 1, Roger Gundle 1, Mark Rogers 1, Adrian Taylor 1, Guy E Thwaites 5, Philip Bejon 5

1 Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
2 Division of Infectious Diseases, Imperial College London, London, UK
3 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK
4 MRC Clinical Trials Unit, University College London, London, UK
5 Nuffield Department of Medicine, University of Oxford, Oxford, UK
6 Green Templeton College, University of Oxford, Oxford, UK
7 Department of Microbiology and Public Health, University Hospital of Wales, Public Health Wales, Cardiff, Wales
8 Department of Orthopaedic Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
9 Infectious Diseases and Microbiology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK
10 Infectious Diseases and Microbiology, Royal Free London NHS Foundation Trust, London, UK
11 Department of Microbiology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
12 Infectious Diseases and Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
13 Infectious Diseases, Heart of England NHS Foundation Trust, Birmingham, UK
14 Infectious Diseases and Microbiology, Gartnaval General Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK
15 Department of Microbiology and Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
16 Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
17 Department of Microbiology and Infectious Diseases, Ninewells Hospital, NHS Tayside, Dundee, UK
18 Infectious Diseases, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK
19 Infectious Diseases Unit, Regional Infectious Diseases Unit, Western General Hospital, NHS Lothian, Edinburgh, UK
20 Health Economics and Health Technology Assessment, University of Glasgow, Glasgow, UK
21 National Infection Service, Public Health England, Horsham, UK
22 Patient and Public Representative, Division of Health and Social Care Research, King’s College London, , London, UK
* Corresponding author Email: Matthew.Scarborough@ouh.nhs.uk

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