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Adding low-dose oral theophylline to inhaled corticosteroids did not reduce exacerbations over 1 year.

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Graham Devereux 1,*, Seonaidh Cotton 2, Shona Fielding 3, Nicola McMeekin 4, Peter J Barnes 5, Andy Briggs 4, Graham Burns 6, Rekha Chaudhuri 7, Henry Chrystyn 8, Lisa Davies 9, Anthony De Soyza 10, Simon Gompertz 11, John Haughney 7, Karen Innes 2, Joanna Kaniewska 2, Amanda Lee 3, Alyn Morice 12, John Norrie 13, Anita Sullivan 11, Andrew Wilson 14, David Price 1,15

1 Respiratory Medicine, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, UK
2 Centre for Healthcare Randomised Trials (CHaRT), University of Aberdeen, Aberdeen, UK
3 Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK
4 Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK
5 National Heart and Lung Institute, Imperial College London, London, UK
6 Department of Respiratory Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, UK
7 Gartnavel General Hospital, University of Glasgow, Glasgow, UK
8 Inhalation Consultancy Ltd, Leeds, UK
9 Aintree Chest Centre, University Hospital Aintree, Liverpool, UK
10 Medical School, Newcastle University, Newcastle upon Tyne, UK
11 Queen Elizabeth Hospital Birmingham, Birmingham, UK
12 Cardiovascular and Respiratory Studies, Castle Hill Hospital, Cottingham, UK
13 Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK
14 Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, UK
15 Academic Primary Care, University of Aberdeen, Aberdeen, UK
* Corresponding author Email: g.devereux@abdn.ac.uk

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