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Of two interferon-gamma release assays, T-SPOT.TB was more sensitive than QFT-GIT in diagnosing active TB, but both were insufficiently sensitive for ruling out active TB in routine UK clinical practice.

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Yemisi Takwoingi 1, Hilary Whitworth 2,3, Melanie Rees-Roberts 2,4, Amarjit Badhan 2,4, Christopher Partlett 1, Nathan Green 5,6,7,8, Aime Boakye 2,4, Heather Lambie 2, Luigi Marongiu 2, Mark Jit 8,9, Peter White 5,6,7,8, Jonathan J Deeks 1, Onn Min Kon 2,4,10, Ajit Lalvani 2,4,*

1 Institute of Applied Health Research, University of Birmingham, Birmingham, UK
2 Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London, London, UK
3 Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK
4 National Institute for Health Research (NIHR) Health Protection Research Unit in Respiratory Infections, Imperial College London, London, UK
5 NIHR Health Protection Research Unit in Modelling Methodology, Imperial College London, London, UK
6 Medical Research Council (MRC) Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
7 Department of Infectious Disease Epidemiology, Imperial College London, London, UK
8 Modelling and Economics Unit, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK
9 Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
10 St Mary’s Hospital, Imperial College Healthcare Trust, London, UK
* Corresponding author Email: a.lalvani@imperial.ac.uk

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