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This study identified barriers to delivering a full trial, including acceptability of the permissive temperature threshold, and provides insight into how these barriers may be overcome.

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Mark J Peters 1,*, Imran Khan 2, Kerry Woolfall 3, Elizabeth Deja 3, Paul R Mouncey 2, Jerome Wulff 2, Alexina Mason 2, Rachel Agbeko 4, Elizabeth S Draper 5, Blaise Fenn 6, Doug W Gould 2, Abby Koelewyn 2, Nigel Klein 7, Christine Mackerness 4, Sian Martin 2, Lauran O’Neill 1, Padmanabhan Ramnarayan 8, Shane Tibby 9, Lyvonne Tume 10, Jason Watkins 6, Kent Thorburn 11, Paul Wellman 9, David A Harrison 2, Kathryn M Rowan 2

1 Respiratory, Critical Care and Anaesthesia Unit, University College London Great Ormond Street Institute of Child Health, London, UK
2 Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK
3 Department of Psychological Sciences, North West Hub for Trials Methodology, University of Liverpool, Liverpool, UK
4 Paediatric Intensive Care Unit, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
5 Department of Health Sciences, University of Leicester, Leicester, UK
6 Patient/Parent Representative, London, UK
7 Institute of Child Health, University College London, London, UK
8 Children’s Acute Transport Service, Great Ormond Street Hospital, London, UK
9 Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
10 Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK
11 Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
* Corresponding author Email:

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