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Adding PET/CT to standard diagnostic workup in suspected pancreatic cancer significantly improved relative sensitivity and specificity, as well as significantly influencing the staging and management of patients, and was highly likely to be cost-effective for the NHS.

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Paula Ghaneh 1,*, Robert Hanson 2, Andrew Titman 3, Gill Lancaster 3, Catrin Plumpton 4, Huw Lloyd-Williams 4, Seow Tien Yeo 4, Rhiannon Tudor Edwards 4, Colin Johnson 5, Mohammed Abu Hilal 6, Antony P Higginson 7, Tom Armstrong 6, Andrew Smith 8, Andrew Scarsbrook 9, Colin McKay 10, Ross Carter 10, Robert P Sutcliffe 11, Simon Bramhall 12, Hemant M Kocher 13, David Cunningham 14, Stephen P Pereira 15, Brian Davidson 16, David Chang 17, Saboor Khan 18, Ian Zealley 19, Debashis Sarker 20, Bilal Al Sarireh 21, Richard Charnley 22, Dileep Lobo 23, Marianne Nicolson 24, Christopher Halloran 1, Michael Raraty 25, Robert Sutton 25, Sobhan Vinjamuri 26, Jonathan Evans 27, Fiona Campbell 28, Jon Deeks 29, Bal Sanghera 30, Wai-Lup Wong 30, John P Neoptolemos 1

1 Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
2 Liverpool Cancer Research UK Cancer Trials Unit, University of Liverpool, Liverpool, UK
3 Department of Mathematics and Statistics, Lancaster University, Lancaster, UK
4 Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, UK
5 Faculty of Medicine, University of Southampton, Southampton, UK
6 Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK
7 Department of Radiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK
8 Department of Gastrointestinal Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK
9 Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
10 Department of Surgery, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UK
11 Department of Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
12 Department of General Surgery, Wye Valley NHS Trust, Hereford, UK
13 Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, London, UK
14 Gastrointestinal and Lymphoma Unit, Royal Marsden NHS Foundation Trust, London, UK
15 Institute for Liver and Digestive Health, University College London Hospitals NHS Foundation Trust, London, UK
16 Department of Surgery, Royal Free London NHS Foundation Trust, London, UK
17 Department of Surgery, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust, Blackburn, UK
18 Department of Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
19 Department of Surgery, Ninewells Hospital and Medical School, NHS Tayside, Dundee, UK
20 Department of Oncology, King’s College Hospital NHS Foundation Trust, London, UK
21 Department of Surgery, Morriston Hospital, Abertawe Bro Morgannwg University Health Board, Swansea, UK
22 Department of Surgery, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
23 Faculty of Medicine and Life Sciences, University of Nottingham, Nottingham, UK
24 Department of Oncology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK
25 Department of Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
26 Department of Nuclear Medicine, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
27 Department of Radiology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
28 Department of Pathology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
29 Institute of Applied Health Research, University of Birmingham, Birmingham, UK
30 Paul Strickland Scanner Centre, Mount Vernon Hospital, Middlesex, UK
* Corresponding author Email: p.ghaneh@liverpool.ac.uk

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