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The efficacy of BNP-guided-therapy in specialist heart failure clinics is uncertain, but if efficacious, it would be cost-effective for patients under 75 with reduced ejection fraction.

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Maria Pufulete 1, Rachel Maishman 1, Lucy Dabner 1, Syed Mohiuddin 2, William Hollingworth 2, Chris A Rogers 1, Julian Higgins 2, Mark Dayer 3, John Macleod 2, Sarah Purdy 2, Theresa McDonagh 4, Angus Nightingale 5, Rachael Williams 6, Barnaby C Reeves 1,*

1 Clinical Trials and Evaluation Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
2 School of Social and Community Medicine, University of Bristol, Bristol, UK
3 Department of Cardiology, Taunton and Somerset NHS Foundation Trust, Taunton, UK
4 Cardiovascular Division, King’s College London, King’s College Hospital, London, UK
5 Department of Cardiology, Bristol Heart Institute, Bristol Royal Infirmary, Bristol, UK
6 Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, UK
* Corresponding author Email:

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