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The study only randomised two patients and so could not address the benefits of intravenous immunoglobulin, however they identified several recruitment barriers which would need to be overcome in future trials.

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Michael Absoud 1, Peter Brex 2, Olga Ciccarelli 3, Onyinye Diribe 1,4, Gavin Giovannoni 5, Jennifer Hellier 6, Rosemary Howe 4, Rachel Holland 6, Joanna Kelly 4, Paul McCrone 7, Caroline Murphy 4, Jackie Palace 8, Andrew Pickles 6, Michael Pike 9, Neil Robertson 10, Anu Jacob 11, Ming Lim 1,*

1 Department of Children’s Neurosciences, Evelina Children’s Hospital at Guy’s and St Thomas’ NHS Foundation Trust, King’s Health Partners Academic Health Science Centre, London, UK
2 Department of Neurology, King’s College Hospital NHS Foundation Trust, King’s Health Partners Academic Health Science Centre, London, UK
3 University College London Institute of Neurology, London, UK
4 King’s Clinical Trials Unit, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
5 Centre for Neuroscience and Trauma, Blizard Institute, University of London and Barts Health NHS Trust, London, UK
6 Department of Biostatistics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
7 Centre for the Economics of Mental and Physical Health, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
8 Department of Neurology, Oxford University Hospitals NHS Trust, Oxford, UK
9 Department of Paediatric Neurology, Oxford University Hospitals NHS Trust, Oxford, UK
10 Institute of Psychological Medicine and Clinical Neurosciences, Cardiff and Vale University Health Board, Cardiff, UK
11 The Walton Centre, Walton Centre NHS Foundation Trust, Liverpool, UK
* Corresponding author Email: ming.lim@gstt.nhs.uk

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