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The CRISP trial to test the hypothesis that, in high-risk patients, off-pump coronary artery bypass grafting reduces mortality and morbidity without causing a higher risk of reintervention compared with on-pump coronary artery bypass grafting was not successful for a range of logistical reasons. However, the experience gained is of value for the design and conduct of future trials. A qualitative evaluation of the reasons behind the views held by the advocates of the two techniques is an area for future research.

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Chris A Rogers,1,* Katie Pike,1 Helen Campbell,2 Barnaby C Reeves,1 Gianni D Angelini,3 Alastair Gray,2 Doug G Altman,4 Helen Miller,1 Sian Wells,1 David P Taggart,5  , 

1 Clinical Trials and Evaluation Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
2 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK
3 Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK
4 Centre for Statistics in Medicine, University of Oxford, Oxford, UK
5 Nuffield Department of Surgical Science, University of Oxford, Oxford, UK
* Corresponding author ; Email:

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