Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation

Takeda, A; Cooper, K; Bird, A; Baxter, L; Frampton, GK; Gospodarevskaya, E; Welch, K; Bryant, J

doi:10.3310/hta14420

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Study found that treatment with recombinant human growth hormone gave significantly greater benefits in stature for children with growth hormone deficiency (GHD), Turner syndrome, Prader–Willi syndrome, chronic renal insufficency, short stature homeobox-containing gene deficiency, and those who were small for gestational age, than for untreated children. However, treatment was considered to be cost-effective at a willingness to pay threshold of £20,000–30,000 per quality-adjusted life-year gained only for children with GHD, although the analysis is subject to a range of important uncertainties

A Takeda, K Cooper, A Bird, L Baxter, GK Frampton, E Gospodarevskaya, K Welch & J Bryant.

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A Takeda , K Cooper , A Bird , L Baxter , GK Frampton , E Gospodarevskaya , K Welch , J Bryant ^,^*

Southampton Health Technology Assessments Centre (SHTAC), Southampton, UK
^* Corresponding author Email: j.s.bryant@soton.ac.uk

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