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This trial showed that methenamine hippurate is not inferior to the current standard care of daily low-dose antibiotics in preventing recurrent urinary tract infections in women during 12 months of prophylactic treatment.

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Chris Harding 1,2,*, Thomas Chadwick 3, Tara Homer 3, Jan Lecouturier 3, Helen Mossop 3, Sonya Carnell 4, Will King 3, Alaa Abouhajar 4, Luke Vale 3, Gillian Watson 4, Rebecca Forbes 4, Stephanie Currer 4, Robert Pickard 5,†, Ian Eardley 6, Ian Pearce 7, Nikesh Thiruchelvam 8, Karen Guerrero 9, Katherine Walton 10, Zahid Hussain 11, Henry Lazarowicz 12, Ased Ali 13

1 Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK
2 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
3 Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK
4 Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
5 Institute of Cellular Medicine, The Medical School, Newcastle upon Tyne, UK
6 Leeds Teaching Hospitals NHS Trust, Leeds, UK
7 Manchester University NHS Foundation Trust, Manchester, UK
8 Addenbrooke’s Hospital, Cambridge, UK
9 Queen Elizabeth University Hospital, Glasgow, UK
10 Department of Microbiology, Freeman Hospital, Newcastle upon Tyne, UK
11 The Royal Oldham Hospital, Oldham, UK
12 Liverpool University Hospitals NHS Foundation Trust, formerly The Royal Liverpool University Hospital, Liverpool, UK
13 Urology Department, Pinderfields Hospital, Wakefield, UK
* Corresponding author Email: C.Harding@nhs.net

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