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Although this study successfully obtained consent from patients, doing this routinely would not be possible, and since hospital data were also not uniformly available, a national registry is not feasible.

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Jessica M Harris 1, Rachel C Brierley 1, Maria Pufulete 1, Chiara Bucciarelli-Ducci 2, Elizabeth A Stokes 3, John P Greenwood 4, Stephen H Dorman 2, Richard A Anderson 5, Chris A Rogers 1, Sarah Wordsworth 3, Sunita Berry 6, Barnaby C Reeves 1,*

1 Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, UK
2 National Institute for Health Research (NIHR) Bristol Cardiovascular Research Unit, Bristol Heart Institute, University of Bristol, Bristol, UK
3 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK
4 Multidisciplinary Cardiovascular Research Centre and Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
5 University Hospitals of Wales, Cardiff, UK
6 NHS England, South West Clinical Networks and Senate, Bristol, UK
* Corresponding author Email: barney.reeves@bristol.ac.uk

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