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There was evidence that the treatment period risks varied with the medication, but buprenorphine as an alternative to methadone may not reduce mortality overall due to shorter treatment duration.

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Colin D Steer 1,*, John Macleod 1, Kate Tilling 1, Aaron G Lim 1, John Marsden 2, Tim Millar 3, John Strang 2, Maggie Telfer 4, Heather Whitaker 5, Peter Vickerman 1, Matthew Hickman 1

1 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
2 National Addiction Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
3 Centre for Mental Health and Safety, School of Health Sciences, University of Manchester, Manchester, UK
4 Bristol Drug Project, Bristol, UK
5 Department of Mathematics and Statistics, The Open University, Milton Keynes, UK
* Corresponding author Email:

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