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None of the four new tests provided diagnostic accuracy at a clinically useful level, either for all TB cases, or for culture-positive TB.

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Alice Halliday 1,2, Pooja Jain 1,3,, Long Hoang 1,, Robert Parker 1,, Mica Tolosa-Wright 1,, Tereza Masonou 1, Nathan Green 4,5,6,7, Aime Boakye 1,3, Yemisi Takwoingi 8,9, Shea Hamilton 10, Vinay Mandagere 1, Anastasia Fries 1, Lachlan Coin 11, Jon Deeks 8,9, Peter J White 4,5,6,7, Michael Levin 10, Peter Beverley 1, Onn Min Kon 1,3,12, Ajit Lalvani 1,3,*

1 TB Research Centre, National Heart and Lung Institute, Imperial College London, London, UK
2 Cellular and Molecular Medicine, University of Bristol, Bristol, UK
3 National Institute for Health Research, Health Protection Research Unit in Respiratory Infection, Imperial College London, London, UK
4 National Institute for Health Research, Health Protection Research Unit in Modelling Methodology, Imperial College London, London, UK
5 Medical Research Council, Centre for Global Infectious Disease Analysis, Imperial College London, London, UK
6 Modelling and Economics Unit, National Infection Service, Public Health England, London, UK
7 Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
8 Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
9 National Institute for Health Research, Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, University of Birmingham, Birmingham, UK
10 Paediatric Infectious Diseases Group, Division of Medicine, Imperial College London, London, UK
11 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
12 St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK
* Corresponding author Email: a.lalvani@imperial.ac.uk

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