Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT

Chappell, Lucy C; Bell, Jennifer L; Smith, Anne; Rounding, Catherine; Bowler, Ursula; Linsell, Louise; Juszczak, Edmund; Tohill, Sue; Redford, Amanda; Dixon, Peter H; Chambers, Jenny; Hunter, Rachael; Dorling, Jon; Williamson, Catherine; Thornton, Jim G

doi:10.3310/eme07090

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This trial showed ursodeoxycholic acid does not reduce adverse perinatal outcomes in intrahepatic cholestasis of pregnancy.

Lucy C Chappell , Jennifer L Bell , Anne Smith , Catherine Rounding , Ursula Bowler , Louise Linsell , Edmund Juszczak , Sue Tohill , Amanda Redford , Peter H Dixon , Jenny Chambers , Rachael Hunter , Jon Dorling , Catherine Williamson & Jim G Thornton .

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Lucy C Chappell ^1,^*, Jennifer L Bell ², Anne Smith ², Catherine Rounding ², Ursula Bowler ², Louise Linsell ², Edmund Juszczak ², Sue Tohill ¹, Amanda Redford ³, Peter H Dixon ¹, Jenny Chambers ⁴, Rachael Hunter ⁵, Jon Dorling ⁶, Catherine Williamson ^1,^†, Jim G Thornton ^3,^†

¹ Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
² National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
³ Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK
⁴ ICP Support, Sutton Coldfield, UK
⁵ Research Department of Primary Care and Population Health, University College London, London, UK
⁶ Division of Neonatal-Perinatal Medicine, IWK Health Centre, Halifax, NS, Canada
^* Corresponding author Email: lucy.chappell@kcl.ac.uk

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