Mini-combined test compared with NICE guidelines for early risk-assessment for pre-eclampsia: the SPREE diagnostic accuracy study

Poon, Liona C; Wright, David; Thornton, Steve; Akolekar, Ranjit; Brocklehurst, Peter; Nicolaides, Kypros H

doi:10.3310/eme07080

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This study demonstrated that the performance of first-trimester screening for pre-eclampsia by a combination of maternal factors and biomarkers was superior to that achieved by current NICE guidelines.

Liona C Poon , David Wright , Steve Thornton , Ranjit Akolekar , Peter Brocklehurst & Kypros H Nicolaides .

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Liona C Poon ¹, David Wright ², Steve Thornton ³, Ranjit Akolekar ⁴, Peter Brocklehurst ⁵, Kypros H Nicolaides ^1,^*

¹ Fetal Medicine Research Institute, King’s College Hospital, King’s College London, London, UK
² Institute of Health Services Research, University of Exeter, Exeter, UK
³ Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
⁴ Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Kent, UK
⁵ Comprehensive Clinical Trials Unit, University College London, London, UK
^* Corresponding author Email: kypros@fetalmedicine.com

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