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Adjunctive intracoronary alteplase at low-dose (20mg or 10mg) given during the primary percutaneous intervention compared with placebo did not reduce microvascular obstruction.

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Peter J McCartney 1,2, Hany Eteiba 1,2, Annette M Maznyczka 1,2, Margaret McEntegart 1,2, John P Greenwood 3, Douglas F Muir 4, Saqib Chowdhary 5, Anthony H Gershlick 6, Clare Appleby 7, James M Cotton 8, Andrew Wragg 9, Nick Curzen 10, Keith G Oldroyd 2, Mitchell Lindsay 2, J Paul Rocchiccioli 2, Aadil Shaukat 2, Richard Good 2, Stuart Watkins 2, Keith Robertson 2, Christopher Malkin 3, Lynn Martin 2, Lynsey Gillespie 11, Thomas J Ford 1, Mark C Petrie 1,2, Peter W Macfarlane 12, R Campbell Tait 13, Paul Welsh 1, Naveed Sattar 1, Robin A Weir 14, Keith A Fox 15, Ian Ford 16, Alex McConnachie 16, Colin Berry 1,2

1 British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
2 West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK
3 Leeds University and Leeds Teaching Hospitals NHS Trust, Leeds, UK
4 The James Cook University Hospital, South Tees Hospitals NHS Trust, Middlesbrough, UK
5 Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK
6 University Hospitals of Leicester NHS Trust, Leicester, UK
7 Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK
8 Royal Wolverhampton NHS Trust, Wolverhampton, UK
9 Barts Health NHS Trust and The Royal London Hospital, London, UK
10 University Hospital Southampton Foundation Trust, Southampton, UK
11 NHS Greater Glasgow and Clyde Board, Glasgow, UK
12 Electrocardiography Core Laboratory, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
13 Department of Haematology, Glasgow Royal Infirmary, Glasgow, UK
14 University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, UK
15 College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
16 Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
* Corresponding author Email: colin.berry@glasgow.ac.uk

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