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Treatment with spironolactone, compared with placebo, did not improve exercise tolerance at 2 years for people experiencing atrial fibrillation and preserved ejection fraction.

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Eduard Shantsila 1,2,3,4,*, Farhan Shahid 1,2, Yongzhong Sun 5, Jonathan J Deeks 5,6, Ronnie Haynes 2,7, Melanie Calvert 5,8, James P Fisher 9, Paulus Kirchhof 1,2,10, Paramjit S Gill 11, Gregory YH Lip 4

1 Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
2 Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
3 North Worcestershire VTS, Health Education England (West Midlands), St Helens and Knowsley Teaching Hospitals NHS Trust, Whiston, Merseyside, UK
4 Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK
5 NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK
6 Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
7 The Surgery, Birmingham, UK
8 Centre for Patient Reported Outcomes Research (CPROR), Institute of Applied Health Research, University of Birmingham, Birmingham, UK
9 Faculty of Medical and Health Sciences, Department of Physiology, University of Auckland, Auckland, New Zealand
10 University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
11 Academic Unit of Primary Care, Warwick Medical School, University of Warwick, Coventry, UK
* Corresponding author Email: Eduard.Shantsila@liverpool.ac.uk

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