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Amiloride, fluoxetine and riluzole were not effective in reducing the brain volume loss in people with secondary progressive MS over 96 weeks.

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Floriana De Angelis 1, Peter Connick 2, Richard A Parker 3, Domenico Plantone 1, Anisha Doshi 1, Nevin John 1, Jonathan Stutters 1, David MacManus 1, Ferran Prados 1,4,5, Ian Marshall 2, Bhavana Solanky 1, Rebecca S Samson 1, Frederik Barkhof 1,4,6, Sebastien Ourselin 7, Marie Braisher 1, Moira Ross 3, Gina Cranswick 3, Sue H Pavitt 8, Sharmilee Gnanapavan 9, Gavin Giovannoni 9, Claudia AM Gandini Wheeler-Kingshott 1,10, Clive Hawkins 11, Basil Sharrack 12, Roger Bastow 13, Christopher J Weir 3, Nigel Stallard 14, Siddharthan Chandran 2, Jeremy Chataway 1,15,*

1 Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, Department of Neuroinflammation, Faculty of Brain Sciences, University College London, London, UK
2 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
3 Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK
4 Department of Medical Physics and Biomedical Engineering, Centre for Medical Image Computing, University College London, London, UK
5 eHealth Centre, Universitat Oberta de Catalunya, Barcelona, Spain
6 Department of Radiology and Nuclear Medicine, Vrije Universiteit University Medical Centre, Amsterdam, the Netherlands
7 School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK
8 Dental Translational and Clinical Research Unit (part of the National Institute for Health Research Leeds Clinical Research Facility), University of Leeds, Leeds, UK
9 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
10 Brain MRI 3T Research Center, Istituto di Ricovero e Cura a Carattere Scientifico, Mondino Foundation, Pavia, Italy
11 Keele Medical School and Institute for Science and Technology in Medicine, Keele University, Keele, UK
12 Department of Neuroscience, Royal Hallamshire Hospital, Sheffield, UK
13 UK MS Society patient representative, MS National Centre, London, UK
14 Statistics and Epidemiology, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK
15 National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, UK
* Corresponding author Email: j.chataway@ucl.ac.uk

A list of MS-SMART Investigators is provided in the Acknowledgements.

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