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This large trial showed levothyroxine therapy in a dose of 50mcg per day did not improve live birth rates in euthyroid women with thyroid antibodies.

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Rima K Dhillon-Smith 1,2,3, Lee J Middleton 4, Kirandeep K Sunner 4, Versha Cheed 4, Krys Baker 5, Samantha Farrell-Carver 4, Ruth Bender-Atik 6, Rina Agrawal 7, Kalsang Bhatia 8, Edmond Edi-Osagie 9, Tarek Ghobara 7, Pratima Gupta 10, Davor Jurkovic 11, Yacoub Khalaf 12, Marjory MacLean 13, Chris McCabe 1, Khashia Mulbagal 14, Natalie Nunes 15, Caroline Overton 16, Siobhan Quenby 7, Rajendra Rai 17, Nick Raine-Fenning 18,19, Lynne Robinson 3, Jackie Ross 20, Andrew Sizer 21, Rachel Small 9, Alex Tan 22, Martyn Underwood 21, Mark D Kilby 1,3, Kristien Boelaert 1, Jane Daniels 23, Shakila Thangaratinam 22, Shiao-Yng Chan 24, Arri Coomarasamy 1,2,3,*

1 Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
2 Tommy’s Centre for Miscarriage Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
3 Centre for Women’s and Newborn Health, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK
4 Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
5 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
6 The Miscarriage Association, Wakefield, UK
7 University Hospital Coventry, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK
8 Burnley General Hospital, East Lancashire Hospitals NHS Trust, Burnley, UK
9 Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK
10 Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
11 University College Hospital, University College London Hospitals NHS Foundation Trust, London, UK
12 Assisted Conception Unit, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
13 Ayrshire Maternity Unit, University Hospital Crosshouse, NHS Ayrshire and Arran, Kilmarnock, UK
14 Royal Bolton Hospital, Bolton NHS Foundation Trust, Farnworth, UK
15 West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
16 St Michael’s Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
17 St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK
18 Division of Child Health, Obstetrics and Gynaecology, Nottingham, UK
19 Nurture Fertility, The Fertility Partnership, Nottingham, UK
20 Early Pregnancy and Gynaecology Assessment Unit, King’s College Hospital NHS Foundation Trust, London, UK
21 The Princess Royal Hospital, The Shrewsbury and Telford Hospital NHS Trust, Telford, UK
22 Barts Research Centre for Women’s Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
23 Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK
24 Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, , Singapore
* Corresponding author Email: a.coomarasamy@bham.ac.uk

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