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Minocycline had no effect on negative symptoms of schizophrenia and had no effect on any of the biomarkers of inflammation or neurodegeneration.

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Bill Deakin 1,2,3,*, John Suckling 4,5, Paola Dazzan 6, Eileen Joyce 7, Stephen M Lawrie 8, Rachel Upthegrove 9, Nusrat Husain 10,11, Imran B Chaudhry 11,12, Graham Dunn 13,, Peter B Jones 4,5, Danuta Lisiecka-Ford 4, Shôn Lewis 1,2,3, Thomas RE Barnes 14, Steven CR Williams 15, Carmine M Pariante 16, Emma Knox 1, Richard J Drake 2,10, Richard Smallman 1, Nicholas M Barnes 17

1 Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK
2 Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK
3 Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, Manchester, UK
4 Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
5 Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK
6 Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
7 Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
8 Division of Psychiatry, University of Edinburgh, Edinburgh, UK
9 Institute for Mental Health, University of Birmingham, Birmingham, UK
10 Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
11 Lancashire Care Early Intervention Service, Accrington, UK
12 Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
13 Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
14 Centre for Psychiatry, Department of Medicine, Imperial College London, London, UK
15 Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
16 Stress, Psychiatry and Immunology Lab & Perinatal Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK
17 Institute of Clinical Sciences, University of Birmingham, Birmingham, UK
* Corresponding author Email: bill.deakin@manchester.ac.uk

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