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Ketamine showed no cognitive or other benefit when given alongside ECT, but the study recruited fewer participants than planned and moderate benefits or harms cannot be excluded.

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Ian M Anderson 1,*, Andrew Blamire 2, Tim Branton 3, Sabrina Brigadoi 4,5, Ross Clark 6, Darragh Downey 1, Graham Dunn 7, Andrew Easton 8, Rebecca Elliott 1, Clare Elwell 4, Katherine Hayden 9, Fiona Holland 7, Salman Karim 10, Jo Lowe 1, Colleen Loo 11, Rajesh Nair 12, Timothy Oakley 13, Antony Prakash 14, Parveen K Sharma 15, Stephen R Williams 16, R Hamish McAllister-Williams 13,17

1 Neuroscience and Psychiatry Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
2 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
3 Leeds and York Partnership NHS Foundation Trust, Leeds, UK
4 Biomedical Optics Research Laboratory, University College London, London, UK
5 Department of Developmental and Social Psychology, University of Padova, Padova, Italy
6 Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
7 Centre for Biostatistics, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
8 Nuffield Health, Leeds, UK
9 Pennine Care NHS Foundation Trust, Stockport, UK
10 Lancashire Care NHS Foundation Trust and University of Manchester, Preston, UK
11 School of Psychiatry, University of New South Wales, Black Dog Institute and St George Hospital, Sydney, NSW, Australia
12 Tees, Esk and Wear Valleys NHS Foundation Trust, Darlington, UK
13 Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK
14 Derbyshire Healthcare NHS Foundation Trust, Derby, UK
15 Manchester Mental Health and Social Care Trust, Manchester, UK
16 Centre for Imaging Science, University of Manchester, Manchester, UK
17 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
* Corresponding author Email: ian.anderson@manchester.ac.uk

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