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Intracoronary adenosine or sodium nitroprusside during primary percutaneous coronary intervention for ST-elevation myocardial infarction did not reduce infarct size and there was evidence of mid-term harm with adenosine.

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Sheraz A Nazir 1, Jamal N Khan 1, Islam Z Mahmoud 2, John P Greenwood 3, Daniel J Blackman 3, Vijay Kunadian 4, Martin Been 5, Keith R Abrams 6, Robert Wilcox 7, AA Jennifer Adgey 8, Gerry P McCann 1, Anthony H Gershlick 1,*

1 Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
2 Department of Cardiovascular Imaging, Division of Imaging Sciences & Biomedical Engineering, Rayne Institute, BHF Excellence Centre, St Thomas’ Hospital, King’s College London, London, UK
3 Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
4 Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
5 Department of Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
6 Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, School of Medicine, University of Leicester, Leicester, UK
7 Faculty of Medicine and Health Sciences, Queen’s Medical Centre, Nottingham, UK
8 Heart Centre, Royal Victoria Hospital, Belfast, UK
* Corresponding author Email:

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