The REFLO-STEMI (REperfusion Facilitated by LOcal adjunctive therapy in ST-Elevation Myocardial Infarction) trial: a randomised controlled trial  comparing intracoronary administration of adenosine or sodium nitroprusside with control for attenuation of microvascular obstruction during primary percutaneous coronary intervention

Nazir, Sheraz A; Khan, Jamal N; Mahmoud, Islam Z; Greenwood, John P; Blackman, Daniel J; Kunadian, Vijay; Been, Martin; Abrams, Keith R; Wilcox, Robert; Adgey, AA Jennifer; McCann, Gerry P; Gershlick, Anthony H

doi:10.3310/eme03090

An error occurred retrieving content to display, please try again.

Page not found (404)

Sorry - the page you requested could not be found.

Please choose a page from the navigation or try a website search above to find the information you need.

Extended Research Article

Toolkit

View Award

Intracoronary adenosine or sodium nitroprusside during primary percutaneous coronary intervention for ST-elevation myocardial infarction did not reduce infarct size and there was evidence of mid-term harm with adenosine.

Sheraz A Nazir, Jamal N Khan, Islam Z Mahmoud, John P Greenwood, Daniel J Blackman, Vijay Kunadian, Martin Been, Keith R Abrams, Robert Wilcox, AA Jennifer Adgey, Gerry P McCann & Anthony H Gershlick.

Detailed Author information
Detailed Author information

Sheraz A Nazir ¹, Jamal N Khan ¹, Islam Z Mahmoud ², John P Greenwood ³, Daniel J Blackman ³, Vijay Kunadian ⁴, Martin Been ⁵, Keith R Abrams ⁶, Robert Wilcox ⁷, AA Jennifer Adgey ⁸, Gerry P McCann ¹, Anthony H Gershlick ^1,^*

¹ Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
² Department of Cardiovascular Imaging, Division of Imaging Sciences & Biomedical Engineering, Rayne Institute, BHF Excellence Centre, St Thomas’ Hospital, King’s College London, London, UK
³ Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
⁴ Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
⁵ Department of Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
⁶ Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, School of Medicine, University of Leicester, Leicester, UK
⁷ Faculty of Medicine and Health Sciences, Queen’s Medical Centre, Nottingham, UK
⁸ Heart Centre, Royal Victoria Hospital, Belfast, UK
^* Corresponding author Email: agershlick@aol.com

Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

https://doi.org/{{metadata.DOI}}

Citation: {{author}}{{ (($index < metadata.AuthorsArray.length-1) && ($index <=6)) ? ', ' : '' }}{{(metadata.AuthorsArray.length <= 6) ? '.' : '' }} {{(metadata.AuthorsArray.length > 6) ? 'et al.' : ''}} . {{metadata.JournalShortName}} {{metadata.PublicationDate | date:'yyyy'}};{{metadata.Volume}}({{metadata.Issue}})

Report Content

Full Report
Abstract
Plain English Summary
Plain Language Summary
Scientific Summary

The full text of this issue is available as a PDF document from the Toolkit section on this page.

Responses to this report

No responses have been published.

If you would like to submit a response to this publication, please do so using the form below:

Comments submitted to the NIHR Journals Library are electronic letters to the editor. They enable our readers to debate issues raised in research reports published in the Journals Library. We aim to post within 14 working days all responses that contribute substantially to the topic investigated, as determined by the Editors. Non-relevant comments will be deleted.

Your name and affiliations will be published with your comment.

Once published, you will not have the right to remove or edit your response. The Editors may add, remove, or edit comments at their absolute discretion.

Enter response message*

Name (title, first name, last name)*

Occupation / Job title*

Affiliation / Employer*

Email*

Other authors
For example, if you are responding as a team or group. Please ensure you include full names and separate these using commas

Statement of competing interests
We believe that readers should be aware of any competing interests (conflicts of interest).
The International Committee of Medical Journal Editors (ICMJE) define competing interests as including: financial relationships with industry (for example through employment, consultancies, stock, ownership, honoraria, and expert testimony), either directly or through immediate family; personal relationships; academic competition; and intellectual passion.

If yes, please provide details below

Enter response title*

Enter CAPTCHA What is two plus zero?*

By submitting your response, you are stating that you agree to the terms & conditions