Monoclonal antibody BTT1023 targeting vascular adhesion protein 1 for treating primary sclerosing cholangitis: BUTEO single-arm Phase II trial

Arndtz, Katherine; Chen, Yung-Yi; Rowe, Anna; Homer, Victoria; Kirkham, Amanda; Douglas-Pugh, Jessica; Slade, Daniel; Thorburn, Douglas; Barnes, Eleanor; Aithal, Guruprasad; Newsome, Philip; Smith, David; Adams, David; Weston, Christopher; Hirschfield, Gideon

doi:10.3310/ZPNF4670

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This trial did not show any evidence of efficacy of BTT1023 and as per the protocol and the design of the trial it was discontinued.

Katherine Arndtz , Yung-Yi Chen , Anna Rowe , Victoria Homer , Amanda Kirkham , Jessica Douglas-Pugh , Daniel Slade , Douglas Thorburn , Eleanor Barnes , Guruprasad Aithal , Philip Newsome , David Smith , David Adams , Christopher Weston & Gideon Hirschfield .

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Katherine Arndtz ¹, Yung-Yi Chen ¹, Anna Rowe ², Victoria Homer ², Amanda Kirkham ², Jessica Douglas-Pugh ², Daniel Slade ², Douglas Thorburn ³, Eleanor Barnes ⁴, Guruprasad Aithal ⁵, Philip Newsome ¹, David Smith ⁶, David Adams ¹, Christopher Weston ¹, Gideon Hirschfield ^1,^*

¹ Institute of Biomedical Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK
² Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
³ Liver Services, Royal Free London NHS Foundation Trust, London, UK
⁴ Nuffield Department of Medicine, University of Oxford, Oxford, UK
⁵ Faculty of Medicine and Health Sciences, The University of Nottingham, Nottingham, UK
⁶ Acorda Therapeutics, Inc., Ardsley, NY, USA
^* Corresponding author Email: gideonhirschfield@gmail.com

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